Cross-arm binding efficiency of an EGFR x c-Met bispecific antibody
نویسندگان
چکیده
منابع مشابه
Relative antigen levels affect bispecific antibody behavior 1 Impact of Cell-Surface Antigen Expression on Target Engagement and Function of an EGFR x c- Met Bispecific Antibody*
The efficacy of engaging multiple drug targets using bispecific antibodies (BsAbs) is affected by the relative cell surface protein levels of the respective targets. In this work, the receptor density values were correlated to the in vitro activity of a BsAb (JNJ-61186372) targeting epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (c-Met). Simultaneous binding of th...
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Epidermal growth factor receptor (EGFR) mutant non-small cell lung cancers acquire resistance to EGFR tyrosine kinase inhibitors through multiple mechanisms including c-Met receptor pathway activation. We generated a bispecific antibody targeting EGFR and c-Met (JNJ-61186372) demonstrating anti-tumor activity in wild-type and mutant EGFR settings with c-Met pathway activation. JNJ-61186372 was ...
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ژورنال
عنوان ژورنال: mAbs
سال: 2016
ISSN: 1942-0862,1942-0870
DOI: 10.1080/19420862.2015.1136762